GrAPFI: predicting enzymatic function of proteins from domain similarity graphs
نویسندگان
چکیده
منابع مشابه
Predicting protein function from domain content
MOTIVATION Computational assignment of protein function may be the single most vital application of bioinformatics in the post-genome era. These assignments are made based on various protein features, where one is the presence of identifiable domains. The relationship between protein domain content and function is important to investigate, to understand how domain combinations encode complex fu...
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MOTIVATION Homology search methods are dominated by the central paradigm that sequence similarity is a proxy for common ancestry and, by extension, functional similarity. For determining sequence similarity in proteins, most widely used methods use models of sequence evolution and compare amino-acid strings in search for conserved linear stretches. Probabilistic models or sequence profiles capt...
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ژورنال
عنوان ژورنال: BMC Bioinformatics
سال: 2020
ISSN: 1471-2105
DOI: 10.1186/s12859-020-3460-7